Hydrochloric Acid → HCID 20483506, compound

HRID 647975Notes

Reaction equation

HRID 647975 reaction equation
[CH3:1][C:2]1[C:3]([O:8][CH2:9][CH:10]2[O:14]C(C3C=CC=CC=3)[N:12]([CH:21]([CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH3:22])[CH2:11]2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl>C(O)C>[OH:14][CH:10]([CH2:11][NH:12][CH:21]([CH3:22])[CH2:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH2:9][O:8][C:3]1[C:2]([CH3:1])=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54498909HCID 54498909, compound

Product 1

HCID 20483506HCID 20483506, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 45 g of crude 3-methyl-2-{[2-phenyl-3-(4-phenyl-2-butyl)-oxazolidin-5-yl]-methoxy}-pyridine in 200 ml of ethanol is hydrolysed with 120 ml of 4 N hydrochloric acid for 3 hours at 20° C. analogously to Example 31, and the mixture is worked up. Distillation in a bulb tube at 140°-150° C./0.04 mm Hg gives 2-[2'-hydroxy-3'-(1-methyl-3-phenyl-propylamino)-propoxy]-3-methyl-pyridine as a light yellow oil.

Workup

  1. distillationDistillation in a bulb tube at 140°-150° C./0.04 mm Hg

Sources & evidence

ORD record
ord-cdca085ed2f442deadd94380979a4608
Source dataset
uspto-grants-1983_10
Patent number
US04410530

Reaction notes

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