Methanol → 5-(2-Methoxyethyl)pyrimidine-2,4(1H,3H)-dione

HRID 647989Notes

Reaction equation

HRID 647989 reaction equation
CS([O:5][CH2:6][CH2:7][C:8]1[C:9](=[O:15])[NH:10][C:11](=[O:14])[NH:12][CH:13]=1)(=O)=O.[CH3:16]O>>[CH3:16][O:5][CH2:6][CH2:7][C:8]1[C:9](=[O:15])[NH:10][C:11](=[O:14])[NH:12][CH:13]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 102430992-(2,4-dioxo-1H-pyrimidin-5-yl)ethyl methanesulfonate

Product 1

HCID 152769265-(2-Methoxyethyl)pyrimidine-2,4(1H,3H)-dione

Procedure

6.0 g of 5-(2-methylsulphonyloxyethyl)-uracil are suspended in 100 ml of absolute methanol and the suspension is heated to 120°-130° C. for one hour in a pressure vessel. After cooling to room temperature, the crystals obtained are filtered off and washed with methanol. 5-(2-Methoxyethyl)-uracil, melting point 232°-234° C., is obtained.

Workup

  1. temperaturethe suspension is heated to 120°-130° C. for one hour in a pressure vessel
  2. customthe crystals obtained
  3. filtrationare filtered off
  4. washwashed with methanol

Sources & evidence

ORD record
ord-672667864e3f484699991502dddbbab1
Source dataset
uspto-grants-1983_10
Patent number
US04410530

Reaction notes

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