Sodium Hydroxide → HCID 23715406, compound

HRID 648019Notes

Reaction equation

HRID 648019 reaction equation
[C:1]1([CH3:21])[CH:6]=[CH:5][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH2:16][CH:17]([C:18]([OH:20])=[O:19])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+:23]>CO>[C:1]1([CH3:21])[CH:2]=[CH:3][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH2:16][CH:17]([C:18]([O-:20])=[O:19])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:6]=1.[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13487077HCID 13487077, compound

Product 1

HCID 23715406HCID 23715406, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 283 mg. of 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylic acid in 10 ml. of methanol is added 1 molar equivalent of sodium hydroxide, in the form of a 0.1 N solution. The solvent is then evaporated under reduced pressure and the residue taken up in 2 ml. of methanol, followed by precipitation with ether, to yield crude sodium 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate.

Workup

  1. customThe solvent is then evaporated under reduced pressure
  2. customof methanol, followed by precipitation with ether

Sources & evidence

ORD record
ord-8007df1e69014459a1c7509714c3e22f
Source dataset
uspto-grants-1983_10
Patent number
US04410534

Reaction notes

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