Calcium Carbonate → HCID 20484255, compound

HRID 648020Notes

Reaction equation

HRID 648020 reaction equation
[C:1]1([CH3:21])[CH:6]=[CH:5][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH2:16][CH:17]([C:18]([O-:20])=[O:19])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:3][CH:2]=1.[K+].C(=O)([O-])[O-].[Ca+2:27].[Cl-].[NH4+].[Ca]>Cl.O>[C:1]1([CH3:21])[CH:2]=[CH:3][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH2:16][CH:17]([C:18]([O-:20])=[O:19])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:6]=1.[Ca+2:27].[C:1]1([CH3:21])[CH:2]=[CH:3][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH2:16][CH:17]([C:18]([O-:20])=[O:19])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:6]=1

Participants

7

Reactant 4

HCID 10112Calcium Carbonate2×HCID 25517Ammonium ChlorideHCID 5460341CalciumHCID 23715405HCID 23715405, compound2×

Product 1

HCID 20484255HCID 20484255, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

To a solution of 283 mg. of 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylic acid in 10 ml. of methanol is added 1 molar equivalent of potassium hydroxide, in the form of a 0.1 N solution, thus yielding a solution containing potassium 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate. A solution of 50 mg. of calcium carbonate dissolved in the minimum amount of 1 N hydrochloric acid necessary to effect solution of the calcium carbonate, is buffered with solid ammonium chloride, followed by the further addition of 5 ml. of water. The thus obtained buffered calcium solution is then added to the solution of potassium 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate and the precipitate which forms is collected by filtration, washed with water and air dried, to yield calcium 3-p-toluoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate.

Workup

  1. additionfollowed by the further addition of 5 ml
  2. customThe thus obtained
  3. filtrationthe precipitate which forms is collected by filtration
  4. washwashed with water and air
  5. customdried

Sources & evidence

ORD record
ord-b166242038eb41cbb510c32f9eb606e7
Source dataset
uspto-grants-1983_10
Patent number
US04410534

Reaction notes

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