Triphenylphosphine → HCID 11423824, compound

HRID 648061Notes

Reaction equation

HRID 648061 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9][C:10]#N)[CH:6]=[CH:5][C:4]=1[OH:12].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CO>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:4]=1[OH:12]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 698252HCID 698252, compound

Product 1

HCID 11423824HCID 11423824, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Methoxy-4-thiocyanatophenol (10.2 g) and triphenylphosphine (14.8 g) in dry methanol (150 ml) were heated at reflux under nitrogen for 2 hours. Removal of solvent in vacuo followed by column chromatography on silica gel eluting with diethyl ether/petroleum ether (bp 40°-60°) mixtures (gradient 10 to 50% v/v diethyl ether) gave the phenol as a white solid, m.p. 47°-49°.

Workup

  1. temperatureat reflux under nitrogen for 2 hours
  2. customRemoval of solvent in vacuo

Sources & evidence

ORD record
ord-89d7768b070548f49e3f19434e5d1047
Source dataset
uspto-grants-1983_10
Patent number
US04410548

Reaction notes

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