Chloral → 1,1,1-Trichloro-5-ethyl-2-hydroxy-5-methylheptan-4-one

HRID 648147Notes

Reaction equation

HRID 648147 reaction equation
[C:1]([C:4]([CH2:8][CH3:9])([CH3:7])[CH2:5][CH3:6])(=[O:3])[CH3:2].[O:10]=[CH:11][C:12]([Cl:15])([Cl:14])[Cl:13]>C(O)(=O)C>[Cl:13][C:12]([Cl:15])([Cl:14])[CH:11]([OH:10])[CH2:2][C:1](=[O:3])[C:4]([CH2:8][CH3:9])([CH3:7])[CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 6407ChloralHCID 1405902-Pentanone, 3-ethyl-3-methyl-

Product 1

HCID 131886861,1,1-Trichloro-5-ethyl-2-hydroxy-5-methylheptan-4-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 30 g. portion of the product of Preparation 2, 1-acetyl-1-ethyl-1-methylpropane, was combined with 38.4 g. of chloral and 36 ml. of acetic acid, and was stirred under reflux, under nitrogen, for 4 days. The solvent was then carefully removed under vacuum to obtain 39 g. of the crude product as an amber, viscous oil.

Workup

  1. temperatureunder reflux, under nitrogen, for 4 days
  2. customThe solvent was then carefully removed under vacuum
  3. customto obtain 39 g

Sources & evidence

ORD record
ord-1be3a4899acd480f915000e78359c592
Source dataset
uspto-grants-1983_10
Patent number
US04411753

Reaction notes

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