Chloral → 1,1,1-Trichloro-5-ethyl-2-hydroxy-5-methylheptan-4-one

Participants

Reaction Steps

A 30 g. portion of the product of Preparation 2, 1-acetyl-1-ethyl-1-methylpropane, was combined with 38.4 g. of chloral and 36 ml. of acetic acid, and was stirred under reflux, under nitrogen, for 4 days. The solvent was then carefully removed under vacuum to obtain 39 g. of the crude product as an amber, viscous oil.

Provenance & Evidence