Hydrochloric Acid → HCID 20482426, compound

Participants

Reaction Steps

A mixture of 2-acetamido-4-[2-(4-benzhydrylpiperazin-1-yl)ethyl]thiazole (3.75 g), methanol (26 ml) and conc. hydrochloric acid (13 ml) was refluxed under heating for 2.5 hours. After concentration of the reaction mixture, the concentrate was recrystallized from methanol to obtain white crystals (3.4 g) of 2-amino-4-[2-(4-benzhydrylpiperazin-1-yl)ethyl]thiazole trihydrochloride, mp 188°-190° C.

Provenance & Evidence