Hydrochloric Acid → HCID 20482426, compound

HRID 648213Notes

Reaction equation

HRID 648213 reaction equation
C([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14][CH2:13]2)[N:9]=1)(=O)C.[ClH:31]>CO>[ClH:31].[ClH:31].[ClH:31].[NH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14][CH2:13]2)[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20482397HCID 20482397, compound

Product 1

HCID 20482426HCID 20482426, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-acetamido-4-[2-(4-benzhydrylpiperazin-1-yl)ethyl]thiazole (3.75 g), methanol (26 ml) and conc. hydrochloric acid (13 ml) was refluxed under heating for 2.5 hours. After concentration of the reaction mixture, the concentrate was recrystallized from methanol to obtain white crystals (3.4 g) of 2-amino-4-[2-(4-benzhydrylpiperazin-1-yl)ethyl]thiazole trihydrochloride, mp 188°-190° C.

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 2.5 hours
  3. customAfter concentration of the reaction mixture, the concentrate was recrystallized from methanol

Sources & evidence

ORD record
ord-3d8abcc2cae546a795b8d3e8aca9b0c4
Source dataset
uspto-grants-1983_10
Patent number
US04411900

Reaction notes

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