Hydrochloric Acid → HCID 20482422, compound

Participants

Reaction Steps

A mixture of 2-acetamido-4-[3-(4-benzhydrylpiperazin-1-yl)propyl]thiazole (1.2 g), methanol (25 ml) and conc. hydrochloric acid (6 ml) was refluxed under heating for 5 hours. After concentration of the reaction mixture, the resultant crystals were recrystallized from a mixture of methanol and diethyl ether to obtain white crystals (1.05 g) of 2-amino-4-[3-(4-benzhydrylpiperazin-1-yl)propyl]thiazole trihydrochloride, mp 205°-215° C.

Provenance & Evidence