Hydrochloric Acid → HCID 20482422, compound

HRID 648214Notes

Reaction equation

HRID 648214 reaction equation
C([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16]([CH:19]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)[N:9]=1)(=O)C.[ClH:32]>CO>[ClH:32].[ClH:32].[ClH:32].[NH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][N:16]([CH:19]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:17][CH2:18]2)[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20482391HCID 20482391, compound

Product 1

HCID 20482422HCID 20482422, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-acetamido-4-[3-(4-benzhydrylpiperazin-1-yl)propyl]thiazole (1.2 g), methanol (25 ml) and conc. hydrochloric acid (6 ml) was refluxed under heating for 5 hours. After concentration of the reaction mixture, the resultant crystals were recrystallized from a mixture of methanol and diethyl ether to obtain white crystals (1.05 g) of 2-amino-4-[3-(4-benzhydrylpiperazin-1-yl)propyl]thiazole trihydrochloride, mp 205°-215° C.

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 5 hours
  3. customAfter concentration of the reaction mixture, the resultant crystals were recrystallized from a mixture of methanol and diethyl ether

Sources & evidence

ORD record
ord-2ce0c1aac9434bf888a1e868d06af948
Source dataset
uspto-grants-1983_10
Patent number
US04411900

Reaction notes

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