Hydrochloric Acid → HCID 20482414, compound

Participants

Reaction Steps

A mixture of 2-acetamido-4-(4-benzhydrylpiperazin-1-ylmethyl)-5-chlorothiazole (5.4 g), methanol (50 ml) and conc. hydrochloric acid (12.5 ml) was refluxed under heating for 6 hours. After concentration of the reaction mixture, the resultant crystals were recrystallized from methanol to obtain white crystals (1.3 g) of 2-amino-4-(4-benzhydrylpiperazin-1-ylmethyl)-5-chlorothiazole trihydrochloride, mp 210°-250° C.

Provenance & Evidence