Hydrochloric Acid → HCID 20482414, compound

HRID 648215Notes

Reaction equation

HRID 648215 reaction equation
C([NH:4][C:5]1[S:6][C:7]([Cl:30])=[C:8]([CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:13][CH2:12]2)[N:9]=1)(=O)C.[ClH:31]>CO>[ClH:30].[ClH:31].[ClH:30].[NH2:4][C:5]1[S:6][C:7]([Cl:30])=[C:8]([CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:13][CH2:12]2)[N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20482399HCID 20482399, compound

Product 1

HCID 20482414HCID 20482414, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-acetamido-4-(4-benzhydrylpiperazin-1-ylmethyl)-5-chlorothiazole (5.4 g), methanol (50 ml) and conc. hydrochloric acid (12.5 ml) was refluxed under heating for 6 hours. After concentration of the reaction mixture, the resultant crystals were recrystallized from methanol to obtain white crystals (1.3 g) of 2-amino-4-(4-benzhydrylpiperazin-1-ylmethyl)-5-chlorothiazole trihydrochloride, mp 210°-250° C.

Workup

  1. temperaturewas refluxed
  2. temperatureunder heating for 6 hours
  3. customAfter concentration of the reaction mixture, the resultant crystals were recrystallized from methanol

Sources & evidence

ORD record
ord-26c3d093f0d94b9a94f38a188361dc3d
Source dataset
uspto-grants-1983_10
Patent number
US04411900

Reaction notes

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