HCID 13069221, compound → HCID 13069220, compound

HRID 648224Notes

Reaction equation

HRID 648224 reaction equation
[F:1][C:2]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:3]=1[O:4][C:5]1[CH:13]=[C:9]([C:10](O)=[O:11])[C:8]([C:14](O)=[O:15])=[CH:7][C:6]=1[N+:17]([O-:19])=[O:18]>O1CCCC1>[F:1][C:2]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:3]=1[O:4][C:5]1[CH:13]=[C:9]([CH2:10][OH:11])[C:8]([CH2:14][OH:15])=[CH:7][C:6]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 1

HCID 13069221HCID 13069221, compound

Product 1

HCID 13069220HCID 13069220, compoundYield 68.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

3.36 g of 5-(2,4-difluorophenoxy)-4-nitrophthalic acid in 20 ml of absolute tetrahydrofuran is reduced as described in Example 7(d) with 150 ml of a 0.3-molar borane-tetrahydrofuran complex solution in tetrahydrofuran. After crystallization from ethanol/water and ethyl acetate/hexane, 2.1 g of 5-(2,4-difluorophenoxy)-4-nitrophthalyl alcohol is obtained, mp 123.5°-124.5° C.

Workup

  1. customAfter crystallization from ethanol/water and ethyl acetate/hexane

Sources & evidence

ORD record
ord-1d09404c5b6e427e94f6bc188a17e14e
Source dataset
uspto-grants-1983_10
Patent number
US04411910

Reaction notes

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