4-Chloroaniline → N-(4-chlorophenyl)isoleucine

HRID 648262Notes

Reaction equation

HRID 648262 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[Na].Br[CH:11]([CH:15]([CH3:18])[CH2:16][CH3:17])[C:12]([OH:14])=[O:13]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C@H:11]([C:12]([OH:14])=[O:13])[C@H:15]([CH2:16][CH3:17])[CH3:18])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 78124-ChloroanilineHCID 2604812-Bromo-3-methylpentanoic acidHCID 5360545Sodium

Product 1

HCID 54011701N-(4-chlorophenyl)isoleucine

Procedure

N-(4-chlorophenyl)isoleucine is prepared by the reaction of 4-chloroaniline with the sodium salt of α-bromo-3-methylpentanoic acid neat at 100°.

Sources & evidence

ORD record
ord-1f1a2054c4474990a8161fa97e8e2bf3
Source dataset
uspto-grants-1983_10
Patent number
US04411912

Reaction notes

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