2-Bromoisovaleric acid → HCID 54566757, compound

HRID 648285Notes

Reaction equation

HRID 648285 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH2:5].[Na].Br[CH:15]([CH:19]([CH3:21])[CH3:20])[C:16]([OH:18])=[O:17]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C@H:15]([C:16]([OH:18])=[O:17])[CH:19]([CH3:21])[CH3:20])[CH:6]=[CH:7][C:8]=1[C:9]([F:10])([F:11])[F:12]

Participants

4

Reactant 3

HCID 112682-Bromoisovaleric acidHCID 27359144-Amino-2-fluorobenzotrifluorideHCID 5360545Sodium

Product 1

HCID 54566757HCID 54566757, compound

Procedure

Following the procedure of Example 38, 3-fluoro-4-trifluoromethylaniline is reacted with the sodium salt of α-bromoisovaleric acid to yield N-(3-fluoro-4-trifluoromethylphenyl)valine, which is esterified to yield the m-phenoxybenzyl ester of N-(3-fluoro-4-trifluoromethylphenyl)valine.

Sources & evidence

ORD record
ord-a7d7f2acf69d43859d9a4af6cb53ab93
Source dataset
uspto-grants-1983_10
Patent number
US04411912

Reaction notes

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