HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → N-(2-fluoro-4-trifluoromethylphenyl)valin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-Benzoylbenzaldehyde | HCID 13020168 | — |
| Reactant | 3-(2-Fluoro-4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione | HCID 20482737 | — |
| Reactant | 3-(4-Trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione | HCID 20482786 | — |
| Product | N-(2-fluoro-4-trifluoromethylphenyl)valin | HCID 53766748 | — |
Reaction Steps
Each of 3-(2-fluoro-4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione and 3-(4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione, prepared by the procedure of Example 77, is reacted with m-benzoylbenzaldehyde and potassium cyanide using the procedure of Example 71 to yield the m-benzoyl α-cyanobenzyl ester of N-(2-fluoro-4-trifluoromethylphenyl)valin and the m-benzoyl-α-cyanobenzyl ester of N-(4-trifluoromethylphenyl)valine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04411912 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-5bab8c3f351641cb83f79ba29e2beafe |
| Source note | uspto-grants-1983_10 |