Potassium Cyanide → N-(2-fluoro-4-trifluoromethylphenyl)valin
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH:16]([CH:17]([CH3:19])[CH3:18])[C:15](=[O:20])[O:14]C1=O.FC(F)(F)C1C=CC(N2C(C(C)C)C(=O)OC2=O)=CC=1.C(C1C=C(C=CC=1)C=O)(=O)C1C=CC=CC=1.[C-]#N.[K+]>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][C@H:16]([C:15]([OH:20])=[O:14])[CH:17]([CH3:19])[CH3:18]Participants
5
Procedure
Each of 3-(2-fluoro-4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione and 3-(4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione, prepared by the procedure of Example 77, is reacted with m-benzoylbenzaldehyde and potassium cyanide using the procedure of Example 71 to yield the m-benzoyl α-cyanobenzyl ester of N-(2-fluoro-4-trifluoromethylphenyl)valin and the m-benzoyl-α-cyanobenzyl ester of N-(4-trifluoromethylphenyl)valine.
Sources & evidence
- ORD record
- ord-5bab8c3f351641cb83f79ba29e2beafe
- Source dataset
- uspto-grants-1983_10
- Patent number
- US04411912
Reaction notes
Loading…