反应详情

A mixture of 16 g. of 4-(16-hydroxyhexadecylamino)benzoic acid and 150 g. of 30-32% hydrogen bromide in acetic acid is treated with 30 ml. of concentrated sulfuric acid, stirred under reflux for 8 hours, poured into ice-water, and filtered. The product is washed with water, dried and recrystallized from ether-petroleum ether to yield 4-(16-bromohexadecylamino)benzoic acid as a white, crystalline solid.

1. additionA mixture of 16 g
2. temperatureunder reflux for 8 hours
3. filtrationfiltered
4. washThe product is washed with water
5. customdried
6. customrecrystallized from ether-petroleum ether