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HRID648366

反应详情

EQUATION

反应方程式

HRID 648366 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：CC1(C)[C@H](C(=O)O)[C@@H]1C(O)C1CCSC1=O
HCID70534022

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)[C@@H]2[C@H]1C(=O)O[C@H]2C1CCSC1=O
HCID22824566

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

50 mg of p-toluene sulfonic acid were added to a solution of 6.2 g of the product of Step A in 70 ml of benzene and the mixture was refluxed for 90 minutes while removing the water of reaction by passing the condensed solvent through silica gel to obtain a solution of (1R,4R,5S) 4-[dihydro-2-oxo-3-(2H)-thienyl]-6,6-dimethyl-3-oxabicyclo-(3,1,0)-hexan-2-one which was used as is for the next step.

WORKUP

后处理

  1. temperaturethe mixture was refluxed for 90 minutes
  2. customwhile removing
  3. customthe water of reaction