HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → 6-Ethyl-5-propanoylpyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | 6-Ethyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carboxylic acid | HCID 13236511 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Ethyl-5-propanoylpyridin-2(1H)-one | HCID 13236508 | — |
Reaction Steps
A 15 g portion of 6-ethyl-1,2-dihydro-2-oxo-5-(n-propanoyl)-nicotinic acid was heated in an oil bath at 235°-240° C. for 5 hours, cooled and the reaction mixture dissolved in hot ethanol, treated with decolorizing charcoal and filtered. The filtrate was evaporated in dryness and the residue recrystallized from isopropyl alcohol to yield 8.2 g of 6-ethyl-5-(n-propanoyl)-2(1H)-pyridinone, m.p. 138°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04412077 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-54804d8e4dd445e885a2f4a043888047 |
| Source note | uspto-grants-1983_10 |