Methane → 6-Ethyl-5-propanoylpyridin-2(1H)-one

HRID 648380Notes

Reaction equation

HRID 648380 reaction equation
[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[C:6](=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])C(O)=O)[CH3:2].C>C(O)C>[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[CH:6]=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])[CH3:2]

Participants

4

Reactant 2

HCID 297MethaneHCID 132365116-Ethyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carboxylic acid

Product 1

HCID 132365086-Ethyl-5-propanoylpyridin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 15 g portion of 6-ethyl-1,2-dihydro-2-oxo-5-(n-propanoyl)-nicotinic acid was heated in an oil bath at 235°-240° C. for 5 hours, cooled and the reaction mixture dissolved in hot ethanol, treated with decolorizing charcoal and filtered. The filtrate was evaporated in dryness and the residue recrystallized from isopropyl alcohol to yield 8.2 g of 6-ethyl-5-(n-propanoyl)-2(1H)-pyridinone, m.p. 138°-140° C.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customThe filtrate was evaporated in dryness
  4. customthe residue recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-54804d8e4dd445e885a2f4a043888047
Source dataset
uspto-grants-1983_10
Patent number
US04412077

Reaction notes

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