Hydrochloric Acid → HCID 131712407, compound

HRID 648415Notes

Reaction equation

[CH2:1]([O:4][N:5]=[C:6]([C:33]1[N:34]=[C:35]([NH:38]C=O)[S:36][CH:37]=1)[C:7]([NH:9][CH:10]1[C:31](=[O:32])[N:12]2[C:13]([C:28]([OH:30])=[O:29])=[C:14]([CH2:17][S:18][C:19]3[N:23]([CH2:24][C:25]([OH:27])=[O:26])[N:22]=[N:21][N:20]=3)[CH2:15][S:16][C@H:11]12)=[O:8])[CH2:2][CH3:3].Cl>>[CH2:1]([O:4][N:5]=[C:6]([C:33]1[N:34]=[C:35]([NH2:38])[S:36][CH:37]=1)[C:7]([NH:9][CH:10]1[C:31](=[O:32])[N:12]2[C:13]([C:28]([OH:30])=[O:29])=[C:14]([CH2:17][S:18][C:19]3[N:23]([CH2:24][C:25]([OH:27])=[O:26])[N:22]=[N:21][N:20]=3)[CH2:15][S:16][C@H:11]12)=[O:8])[CH2:2][CH3:3]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 131712402HCID 131712402, compound

Product 1

HCID 131712407HCID 131712407, compoundYield 52.4%

Procedure

7-[2-n-Propoxyimino-2-(2-formamido-1,3-thiazol-4-yl)-acetamido]-3-(1-carboxymethyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer) (2.20 g.) was treated with conc. hydrochloric acid (0.56 g.) according to a similar manner to that of Example 12 to give 7-[2-n-propoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-(1-carboxymethyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer) (1.10 g.).

Sources & evidence

ORD record: ord-99d0a1a9a4aa4de29a3c1711b8147963
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04411898

Reaction notes

Loading…