Hydrochloric Acid → HCID 20144926, compound

HRID 648513Notes

Reaction equation

HRID 648513 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:37])[C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23]3[C:32]4[C:27](=[CH:28][C:29]([C:33]([F:36])([F:35])[F:34])=[CH:30][CH:31]=4)[N:26]=[CH:25][CH:24]=3)=[CH:18][CH:17]=2)[CH2:11][CH2:10]1.[ClH:38]>CO>[ClH:38].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][CH:9]1[CH2:10][CH2:11][N:12]([C:15](=[O:37])[C:16]2[CH:17]=[CH:18][C:19]([NH:22][C:23]3[C:32]4[C:27](=[CH:28][C:29]([C:33]([F:34])([F:35])[F:36])=[CH:30][CH:31]=4)[N:26]=[CH:25][CH:24]=3)=[CH:20][CH:21]=2)[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13825071HCID 13825071, compound

Product 1

HCID 20144926HCID 20144926, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-[(2-Fluorophenyl)thio]-1-[4-[[7-(trifluoromethyl)-4-quinolyl]amino]benzoyl]piperidine (1.34 g) was suspended in methanol. Excess ethanolic hydrochloric acid was added to the suspension and the resulting solution was concentrated in vacuo to give an oil. The oil was triturated in acetone to give 4-[(2-fluorophenyl)thio]-1-[4-[[7-(trifluoromethyl)-4-quinolyl]amino]benzoyl]piperidine hydrochloride (1.11 g) as a powder.

Workup

  1. concentrationthe resulting solution was concentrated in vacuo
  2. customto give an oil
  3. customThe oil was triturated in acetone

Sources & evidence

ORD record
ord-fc02bb25427c42e98107683a331afdbf
Source dataset
uspto-grants-1988_04
Patent number
US04735952

Reaction notes

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