Benzenesulfonyl chloride → HCID 13687308, compound

HRID 64853Notes

Reaction equation

HRID 64853 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[N:4][CH:3]=[N:2]1.C(=O)(O)[O-].[Na+].[C:15]1([S:21](Cl)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>ClCCl>[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][S:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:23])=[O:22])[CH:5]=[N:4][CH:3]=[N:2]1

Participants

5

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 43796821H-1,2,4-Triazole-1-propanamine

Product 1

HCID 13687308HCID 13687308, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred mixture of 1.26 g of 1H-1,2,4-triazole-1-propanamine in 30 ml of dichloromethane containing an excess of saturated sodium bicarbonate solution was added, all at once at room temperature, a solution of 1.27 ml of benzenesulfonyl chloride in 15 ml of dichloromethane. The mixture was stirred at room temperature for 16 hours. The layers were separated. The dichloromethane layer was evaporated in vacuo and gave the compound of the Example as a colorless oil.

Workup

  1. additionwas added
  2. customonce at room temperature
  3. customThe layers were separated
  4. customThe dichloromethane layer was evaporated in vacuo
  5. customgave the compound of the Example as a colorless oil

Sources & evidence

ORD record
ord-e8fb60c6c1dc42468e9cbe61fd2df29f
Source dataset
uspto-grants-1986_09
Patent number
US04610981

Reaction notes

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