methyl 8-oxo-9-phenyl-8H-pyrido[1,2-d]thieno[2,3-f][1,4]thiazepin-11-carboxylate → methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate

HRID 648550Notes

Reaction equation

HRID 648550 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[CH:9]S[C:11]3[CH:15]=[CH:14][S:13][C:12]=3[C:6]2=[C:5]([C:16]([O:18][CH3:19])=[O:17])[CH:4]=[C:3]1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C(C)=CC=CC=1>[O:1]=[C:2]1[C:3]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:4][C:5]([C:16]([O:18][CH3:19])=[O:17])=[C:6]2[N:7]1[CH:8]=[CH:9][C:11]1[CH:15]=[CH:14][S:13][C:12]=12

Participants

3

Reactant 1

HCID 14666703methyl 8-oxo-9-phenyl-8H-pyrido[1,2-d]thieno[2,3-f][1,4]thiazepin-11-carboxylate

Product 1

HCID 14666705methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

4.4 g of methyl 8-oxo-9-phenyl-8H-pyrido[1,2-d]thieno[2,3-f][1,4]thiazepine-11-carboxylate were heated under reflux and under argon together with 90 ml of xylene until the reaction was completed. The solution was evaporated in vacuo and the residue was treated with 100 ml of n-hexane, whereupon the product was removed by filtration. By recrystallization from ethyl acetate, there was obtained methyl 7-oxo-8-phenyl-7H-thieno[2,3-a]quinolizine-10-carboxylate as yellow crystals of m.p. 153°-156°.

Workup

  1. customThe solution was evaporated in vacuo
  2. additionthe residue was treated with 100 ml of n-hexane, whereupon the product
  3. customwas removed by filtration
  4. customBy recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-48b12fc97d724504bae359771d6f06e1
Source dataset
uspto-grants-1988_04
Patent number
US04735940

Reaction notes

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