4-Chlorobenzenesulfonyl chloride → HCID 20235774, compound

HRID 64859Notes

Reaction equation

HRID 64859 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[N:4][CH:3]=[N:2]1.C(=O)(O)[O-].[Na+].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>ClCCl>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:9][CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)(=[O:24])=[O:23])=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 43796821H-1,2,4-Triazole-1-propanamine

Product 1

HCID 20235774HCID 20235774, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred mixture of 1.89 g of 1H-1,2,4-triazole-1-propanamine in 50 ml of dichloromethane containing an excess of saturated sodium bicarbonate solution was added, all at once, 3.17 g of 4-chlorobenzenesulfonyl chloride. Vigorous stirring was continued for 24 hours. The layers were separated and the organic layer was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to give a gum.

Workup

  1. additionwas added
  2. customThe layers were separated
  3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customto give a gum

Sources & evidence

ORD record
ord-9a404917d68a4971bd71c366a87fb9dc
Source dataset
uspto-grants-1986_09
Patent number
US04610981

Reaction notes

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