p-Toluenesulfonic acid monohydrate → HCID 20145110, compound

HRID 648627Notes

Reaction equation

HRID 648627 reaction equation
C([O:5][C:6](=[O:31])[C:7]1[CH:12]=[CH:11][C:10]([CH:13]([CH:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[CH3:18])[C:14]([NH2:16])=[O:15])=[CH:9][CH:8]=1)(C)(C)C.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[N:25]1([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:17]([CH:13]([C:14]([NH2:16])=[O:15])[C:10]2[CH:9]=[CH:8][C:7]([C:6]([OH:31])=[O:5])=[CH:12][CH:11]=2)[CH3:18])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 86742087HCID 86742087, compound

Product 1

HCID 20145110HCID 20145110, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

One hundred milligrams (0.237 mmol) of 4-[(1-(2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid-tert.butyl ester in 5 ml of benzene were heated together with some crystals of p-toluene-sulfonic acid hydrate to reflux temperature for half a day. According to the thin layer chromatogram no starting product could be then detected; however, according to the Rf -value and mass spectrum the desired product was formed.

Workup

  1. temperatureto reflux temperature for half a day

Sources & evidence

ORD record
ord-2346770c794540199540dc3bb25c72b9
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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