HCID 13281044, compound → HCID 13281105, compound

HRID 648647Notes

Reaction equation

HRID 648647 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([NH:28][C:29]([CH2:31][C:32]2[CH:40]=[CH:39][C:35]([C:36]([OH:38])=[O:37])=[CH:34][CH:33]=2)=[O:30])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([NH:28][C:29]([CH2:31][C:32]2[CH:33]=[CH:34][C:35]([C:36]([OH:38])=[O:37])=[CH:39][CH:40]=2)=[O:30])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 13281044HCID 13281044, compound

Product 1

HCID 13281105HCID 13281105, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

An amount of 1.1 gm (2 m mol) of 4-{N-[α-(4-benzyloxyphenyl)-2-piperidino-benzyl]-aminocarbonylmethyl}-benzoic acid was suspended in 200 ml of ethanol and catalytically debenzylated at 50° C., under a hydrogen pressure of 5 bar, in the presence of 0.4 gm of 10% palladium/charcoal. Then, the catalyst was filtered off, and the filtrate was concentrated by evaporation and recrystallized from acetonitrile.

Workup

  1. customcatalytically debenzylated at 50° C., under a hydrogen
  2. filtrationThen, the catalyst was filtered off
  3. concentrationthe filtrate was concentrated by evaporation
  4. customrecrystallized from acetonitrile

Sources & evidence

ORD record
ord-e4e90cf03bce45b88c698be78d8976c0
Source dataset
uspto-grants-1988_04
Patent number
US04735959

Reaction notes

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