HCID 136332153, compound → HCID 136332152, compound

HRID 64865Notes

Reaction equation

HRID 64865 reaction equation
[ClH:1].Cl.[Cl:3][C:4]1[C:13]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][N:7]1[CH2:21][C:20](=[O:22])[NH:19][C:8]1=[N:9]2>CO.[Pd]>[ClH:3].[ClH:1].[N:14]1([C:13]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[N:9]=[C:8]2[NH:19][C:20](=[O:22])[CH2:21][N:7]2[CH2:6]3)[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 1

HCID 136332153HCID 136332153, compound

Product 1

HCID 136332152HCID 136332152, compoundYield 61.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.5 g of 6-chloro-7-pyrrolidino-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one dihydrochloride was dissolved in 50 ml of methanol and catalytically reduced in the presence of 250 mg of 10% palladium-on-charcoal at ambient temperature under atmospheric pressure. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was dried to a solid under reduced pressure to obtain 0.84 g of 7-pyrrolidino-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one dihydrochloride (melting point: above 280° C.).

Workup

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by filtration
  3. customthe filtrate was dried to a solid under reduced pressure

Sources & evidence

ORD record
ord-3473b0d9e76d4082859c599f99760183
Source dataset
uspto-grants-1986_09
Patent number
US04610987

Reaction notes

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