HCID 136332153, compound → HCID 136332152, compound

Participants

Reaction Steps

1.5 g of 6-chloro-7-pyrrolidino-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one dihydrochloride was dissolved in 50 ml of methanol and catalytically reduced in the presence of 250 mg of 10% palladium-on-charcoal at ambient temperature under atmospheric pressure. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was dried to a solid under reduced pressure to obtain 0.84 g of 7-pyrrolidino-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one dihydrochloride (melting point: above 280° C.).

Provenance & Evidence