反应详情

Four hundred twenty-seven milligrams (1 m mol) of 4-{N-[α-(4-methyl-phenyl)-2-piperidino-benzyl]-aminocarbonylmethyl}-benzaldehyde were added to an ethereal solution of 450 mg (2 m mol) of ethyl diethylphosphonoacetate and 100 mg (2 m mol) of 50% sodium hydride. After the mixture had been stirred overnight, water was added, and the resulting mixture was extracted with chloroform and purified by column chromatography on silica gel by use of toluene/ethyl acetate (5:1) as eluant.

1. extractionthe resulting mixture was extracted with chloroform
2. custompurified by column chromatography on silica gel by use of toluene/ethyl acetate (5:1) as eluant