Hydrogen Bromide → 106487-32-5

Participants

Reaction Steps

A mixture of 1.5 g of the product of Example 1 in 15 ml of concentrated hydrobromic acid (d=1.49) was refluxed for 2 hours 30 minutes under an inert atmosphere and after evaporating to dryness under reduced pressure, taking up the residue with benzene, concentrating to dryness, adding 2 ml of ethanol, filtering the crystals obtained, drying under reduced pressure, and purifying by crystallization from ethanol, 1.4 g of 1,3-dihydro-7-hydroxy-4-(3-piperidinyl)-2H-indol-2-one hydrobromide melting at 190° C., then 250° C. were obtained.

Provenance & Evidence