Hydrogen Bromide → 106487-32-5

HRID 648696Notes

Reaction equation

HRID 648696 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2.[BrH:19]>>[BrH:19].[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 13755077HCID 13755077, compound

Product 1

HCID 3065049106487-32-5

Procedure

A mixture of 1.5 g of the product of Example 1 in 15 ml of concentrated hydrobromic acid (d=1.49) was refluxed for 2 hours 30 minutes under an inert atmosphere and after evaporating to dryness under reduced pressure, taking up the residue with benzene, concentrating to dryness, adding 2 ml of ethanol, filtering the crystals obtained, drying under reduced pressure, and purifying by crystallization from ethanol, 1.4 g of 1,3-dihydro-7-hydroxy-4-(3-piperidinyl)-2H-indol-2-one hydrobromide melting at 190° C., then 250° C. were obtained.

Workup

  1. temperaturewas refluxed for 2 hours 30 minutes under an inert atmosphere
  2. customafter evaporating to dryness under reduced pressure
  3. concentrationconcentrating to dryness
  4. additionadding 2 ml of ethanol
  5. filtrationfiltering the crystals
  6. customobtained
  7. customdrying under reduced pressure
  8. custompurifying by crystallization from ethanol, 1.4 g of 1,3-dihydro-7-hydroxy-4-(3-piperidinyl)-2H-indol-2-one hydrobromide melting at 190° C.
  9. custom250° C. were obtained

Sources & evidence

ORD record
ord-2a97210747b147eda31b3a5f92b21ff4
Source dataset
uspto-grants-1988_04
Patent number
US04736034

Reaction notes

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