Hydrogen Bromide → 106487-34-7

HRID 648697Notes

Reaction equation

HRID 648697 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2.[BrH:22]>>[BrH:22].[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH:13]2[CH2:18][CH2:17][CH2:16][N:15]([CH2:19][CH2:20][CH3:21])[CH2:14]2)=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 13755078HCID 13755078, compound

Product 1

HCID 3065051106487-34-7

Procedure

1.55 g of the product of Example 2 in 15 ml of 48% hydrobromic acid were refluxed for 2 hours with stirring under an inert atmosphere. After evaporating to dryness under reduced pressure, crystallizing the oil obtained from ethanol, filtering, washing with ether, drying, and purifying by crystallization from methanol, 1.31 g of 1,3-dihydro-7-hydroxy-4-(1-propyl-3-piperidinyl)-2H-indol-2-one hydrobromide melting at 210° C. were obtained.

Workup

  1. customAfter evaporating to dryness under reduced pressure
  2. customcrystallizing the oil
  3. customobtained from ethanol
  4. filtrationfiltering
  5. washwashing with ether
  6. customdrying
  7. custompurifying by crystallization from methanol

Sources & evidence

ORD record
ord-56cbb7c7fb1c4eea9ae0bee3788d0008
Source dataset
uspto-grants-1988_04
Patent number
US04736034

Reaction notes

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