HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(bromomethyl)benzoate → N-[{1-[(4-Carboxyphenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}methyl]-beta-(2-thienyl)alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| Reactant | L-Phenylalanine, methyl ester | HCID 736234 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (S)-Methyl 2-amino-3-(thiophen-2-yl)propanoate | HCID 10899351 | — |
| Reactant | 2-n-butyl 4-chloro 1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole | HCID 13074095 | — |
| Reactant | N-[{1-[(2 chlorophenyl)methyl]-2-n-butyl-4-chloro-1H-imidazol-5-yl}methyl]phenylalanine | HCID 53988647 | — |
| Product | N-[{1-[(4-Carboxyphenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}methyl]-beta-(2-thienyl)alanine | HCID 44316969 | — |
Reaction Steps
The title compound was prepared following the procedure of Example 3 [(i) method B and (ii)] replacing 2-chlorobenzyl bromide with 4-carbomethoxybenzyl bromide, phenylalanine methyl ester with β-(2-thienyl)alanine methyl ester and sodium cyanoborohydride with sodium borohydride; mp 151°-152° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05248689 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-7b615b850a714ed28667ec5cac687e9c |
| Source note | uspto-grants-1993_09 |