p-Anisoyl chloride → HCID 70452558, compound

HRID 64871Notes

Reaction equation

HRID 64871 reaction equation
[C:1]([Cl:11])(=[O:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[CH:12]([NH:15][C:16](=[O:24])[CH2:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([CH3:14])[CH3:13]>C(Cl)Cl>[ClH:11].[CH:12]([NH:15][C:16](=[O:24])[CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:1](=[O:10])[C:2]2[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=2)[CH2:20][CH2:19]1)([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 100826N-isopropyl-1-piperazineacetamide

Product 1

HCID 70452558HCID 70452558, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 4.6 g of anisic acid chloride in 20 ml of methylene chloride is added dropwise to 5 g of piperazinoacetic acid isopropylamide in 20 ml of methylene chloride at 0° C. The mixture is then stirred at room temperature for 4 hours and subsequently concentrated. The residue is recrystallised from isopropanol.

Workup

  1. concentrationsubsequently concentrated
  2. customThe residue is recrystallised from isopropanol

Sources & evidence

ORD record
ord-8c3022f585c949368e9772787e8e09b8
Source dataset
uspto-grants-1986_09
Patent number
US04610984

Reaction notes

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