Hydrochloric Acid → HCID 20145988, compound

HRID 648809Notes

Reaction equation

HRID 648809 reaction equation
[Cl-:1].[NH4+].[CH3:3][C:4]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[C:8]([CH3:15])[C:5]=1[NH:6][CH3:7].Cl>C(O)C.[Zn]>[ClH:1].[ClH:1].[NH2:12][C:10]1[CH:11]=[C:4]([CH3:3])[C:5]([NH:6][CH3:7])=[C:8]([CH3:15])[CH:9]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 20145990HCID 20145990, compound

Product 1

HCID 20145988HCID 20145988, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 702EthanolSolvent

Procedure

A suspension of 15.5 g of powdered zinc and 0.6 g of ammonium chloride is heated to reflux. After the source of heat has been removed, 0.02 mole (3.6 g) of 2,6-dimethyl-4-nitro-N-methylaniline is added so as to maintain reflux. At the end of the addition, the reaction mixture is filtered boiling into a solution of 0.05 mole of hydrochloric acid in 14 ml of absolute ethanol; the dihydrochloride crystallises from the filtrate. After recrystallisation from an alcohol-water mixture, a white product is obtained:

Workup

  1. temperatureis heated to reflux
  2. temperatureAfter the source of heat
  3. customhas been removed
  4. temperatureto maintain
  5. temperaturereflux
  6. additionAt the end of the addition
  7. filtrationthe reaction mixture is filtered
  8. customthe dihydrochloride crystallises from the filtrate
  9. customAfter recrystallisation from an alcohol-water mixture
  10. customa white product is obtained

Sources & evidence

ORD record
ord-841032db200743629dc6201aa07f435c
Source dataset
uspto-grants-1988_04
Patent number
US04736067

Reaction notes

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