Formaldehyde → HCID 14100463, compound

Participants

Reaction Steps

A mixture of N-phenylpiperazine (0.81 g, 5 m mole), DMF (13.4 ml), absolute ethanol (3,3 ml), 37% aqueous formaldehyde solution (0.43 ml) and dl-1,2-bis(3,5-dioxopiperazin-1-yl)-propane (1.34 g, 5 m mole) was stirred at room temperature for 48 hours. Then, the precipitates thus obtained were collected and were washed with absolute ethanol and then with ether. The washed precipitates were dried under a reduced pressure to give the titled compound (1.39 g; yield 62%). The compound obtained in this Example was proved to be identical with the compound described in Example 10 on the basis of the melting point and IR Spectrum.

Provenance & Evidence