Formaldehyde → HCID 14100463, compound

HRID 648937Notes

Reaction equation

HRID 648937 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13]N(C=O)C.C=O.[O:20]=[C:21]1[NH:26][C:25](=[O:27])[CH2:24][N:23]([CH2:28][CH:29]([N:31]2[CH2:36][C:35](=[O:37])[NH:34][C:33](=[O:38])[CH2:32]2)[CH3:30])[CH2:22]1>C(O)C>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][N:26]3[C:21](=[O:20])[CH2:22][N:23]([CH2:28][CH:29]([N:31]4[CH2:32][C:33](=[O:38])[NH:34][C:35](=[O:37])[CH2:36]4)[CH3:30])[CH2:24][C:25]3=[O:27])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 6228DimethylformamideHCID 70961-PhenylpiperazineHCID 30623Razoxane

Product 1

HCID 14100463HCID 14100463, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-phenylpiperazine (0.81 g, 5 m mole), DMF (13.4 ml), absolute ethanol (3,3 ml), 37% aqueous formaldehyde solution (0.43 ml) and dl-1,2-bis(3,5-dioxopiperazin-1-yl)-propane (1.34 g, 5 m mole) was stirred at room temperature for 48 hours. Then, the precipitates thus obtained were collected and were washed with absolute ethanol and then with ether. The washed precipitates were dried under a reduced pressure to give the titled compound (1.39 g; yield 62%). The compound obtained in this Example was proved to be identical with the compound described in Example 10 on the basis of the melting point and IR Spectrum.

Workup

  1. customThen, the precipitates thus
  2. customobtained
  3. customwere collected
  4. washwere washed with absolute ethanol
  5. customThe washed precipitates
  6. customwere dried under a reduced pressure

Sources & evidence

ORD record
ord-9a31e42a76bf41e98f8e133a377100d1
Source dataset
uspto-grants-1988_04
Patent number
US04737497

Reaction notes

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