Methane → HCID 20144356, compound

HRID 648951Notes

Reaction equation

HRID 648951 reaction equation
[ClH:1].[CH2:2]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:12]=2[CH2:13][C:14](=[O:20])[NH:15]3)[CH2:7][CH2:6]1)[CH2:3][CH3:4].C>C(O)C>[ClH:1].[CH2:2]([N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:12]=2[CH2:13][C:14](=[O:20])[NH:15]3)[CH2:7][CH2:6]1)[CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 297MethaneHCID 20144353HCID 20144353, compound

Product 1

HCID 20144356HCID 20144356, compoundYield 72.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.69 g of the hydrochloride of Example 22 were hydrogenated in 300 ml of ethanol in the presence of 0.8 g of 10% palladized charcoal and the mixture was filtered. The filtrate was evaporated to dryness and the product was crystallized from ethanol to obtain 1.24 g of 1,3-dihydro-4-(1-propyl-piperidin-4-yl)-2H-indol-2-one hydrochloride melting at 270°-275° C.

Workup

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated to dryness
  3. customthe product was crystallized from ethanol

Sources & evidence

ORD record
ord-5dedd18670574de6925d0b7cde2d66aa
Source dataset
uspto-grants-1988_04
Patent number
US04737505

Reaction notes

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