Ethyl formate → 2-(N-Formyl-2-amino-ethyl)-furan

HRID 648963Notes

Reaction equation

HRID 648963 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[O:5][CH:6]=[CH:7][CH:8]=1.[CH:9](OCC)=[O:10]>>[CH:9]([NH:1][CH2:2][CH2:3][C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)=[O:10]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 11328632-(Furan-2-yl)ethan-1-amine

Product 1

HCID 137469342-(N-Formyl-2-amino-ethyl)-furan

Procedure

Here, 2-(2-amino-ethyl)furan (10.0 g, 0.090 mol) is refluxed with ethyl formate (80 ml, 1.0 mol) for 12 hours. The reaction product is concentrated by evaporation and distilled in vacuo.

Workup

  1. concentrationThe reaction product is concentrated by evaporation
  2. distillationdistilled in vacuo

Sources & evidence

ORD record
ord-c39f5eca83bd43319f039e3f8864241f
Source dataset
uspto-grants-1988_04
Patent number
US04737495

Reaction notes

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