反应详情

A mixture of 5-aminooxindol (14 g), 29 g of bis(β-bromoethyl)amine.hydrobromide in 250 ml of ethanol was stirred under reflux for 8 hours and allowed to stand overnight at room temperature. To the mixture was added sodium carbonate (10.1 g) and the mixture was stirred further for 8 hours under reflux. After cooling to room temperature, crystals which precipitated were collected by filtration and recrystallized from a mixture of water and ethanol to give 16 g of 5-(1-piperazinyl)oxindol.hydrobromide.

1. temperatureunder reflux for 8 hours
2. stirringthe mixture was stirred further for 8 hours
3. temperatureunder reflux
4. customcrystals which precipitated
5. filtrationwere collected by filtration
6. customrecrystallized from a mixture of water and ethanol