HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 5-(1-Piperazinyl)oxindol.hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Amino-2-oxindole | HCID 2773213 | — |
| Reactant | Ethanamine, 2-bromo-N-(2-bromoethyl)-, hydrobromide (1:1) | HCID 12692731 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(1-Piperazinyl)oxindol.hydrobromide | HCID 13646031 | 57.7% |
Reaction Steps
A mixture of 5-aminooxindol (14 g), 29 g of bis(β-bromoethyl)amine.hydrobromide in 250 ml of ethanol was stirred under reflux for 8 hours and allowed to stand overnight at room temperature. To the mixture was added sodium carbonate (10.1 g) and the mixture was stirred further for 8 hours under reflux. After cooling to room temperature, crystals which precipitated were collected by filtration and recrystallized from a mixture of water and ethanol to give 16 g of 5-(1-piperazinyl)oxindol.hydrobromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04737501 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-6edf5b510ab443ce936951097c188da6 |
| Source note | uspto-grants-1988_04 |