Water → HCID 10379920, compound

HRID 648998Notes

Reaction equation

HRID 648998 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:12][NH:11][C:10](=[O:13])[C:9]=2[CH3:14])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].[CH3:18][C:19]1[NH:20][CH:21]=[CH:22][N:23]=1.O>CS(C)=O>[CH3:14][C:9]1[C:10](=[O:13])[NH:11][CH2:12][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([N:20]2[CH:21]=[CH:22][N:23]=[C:19]2[CH3:18])=[C:3]([N+:15]([O-:17])=[O:16])[CH:4]=1

Participants

5

Reactant 3

HCID 962WaterHCID 127492-MethylimidazoleHCID 10263496HCID 10263496, compound

Product 1

HCID 10379920HCID 10379920, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
50 °C

Procedure

4-(4-Fluoro-3-nitrophenyl)-1,5-dihydro-3-methyl-2H-pyrrol-2-one (6.5g, 28 mmol) and 2-methylimidazole (6.8 g, 83 mmol) are combined in dimethylsulfoxide (50 mL) and the mixture is heated to 50° C. under a nitrogen atmosphere for 4 hr. The mixture is then cooled to room temperature, and water is added to give a precipitate. The mixture is kept cold for 1 hr, and the precipitate is collected by filtration, washed with water, and air-dried to provide the title compound.

Workup

  1. temperatureThe mixture is then cooled to room temperature
  2. customto give a precipitate
  3. filtrationthe precipitate is collected by filtration
  4. washwashed with water
  5. customair-dried

Sources & evidence

ORD record
ord-58e201f0625e46a687c2e313fbb07937
Source dataset
uspto-grants-1988_04
Patent number
US04737511

Reaction notes

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