Hydroxyamine hydrochloride → HCID 86742103, compound

HRID 649029Notes

Reaction equation

HRID 649029 reaction equation
[CH:1]([C:3]1[N:4]([CH2:12][C:13]#[CH:14])[CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH3:11])=[O:9])=O.Cl.[NH2:16][OH:17]>N1C=CC=CC=1>[CH2:12]([N:4]1[CH:5]=[CH:6][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:3]1[CH:1]=[N:16][OH:17])[C:13]#[CH:14]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 13605014HCID 13605014, compound

Product 1

HCID 86742103HCID 86742103, compoundYield 106.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2 g of the product of Step A, 725 mg of hydroxylamine hydrochloride and 11 ml of anhydrous pyridine were stirred for 3 hours at ambient temperature and the pyridine was then concentrated under reduced pressure. The residue was taken up in ethyl acetate and the solution was washed with water, dried and concentrated to obtain 2.3 g of methyl 1-(2-propynyl)-2-oximinomethyl-3-pyrrole-carboxylate melting at 88°-90° C.

Workup

  1. concentrationthe pyridine was then concentrated under reduced pressure
  2. washthe solution was washed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-c066a091f5d648f59ae786c2d4008fd1
Source dataset
uspto-grants-1988_04
Patent number
US04737513

Reaction notes

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