Sodium Chloride → HCID 13605019, compound

HRID 649031Notes

Reaction equation

HRID 649031 reaction equation
[BH4-].[K+].[N+:3]([C:6]1[C:10]([CH:11]=[O:12])=[CH:9][N:8]([CH2:13][C:14]#[CH:15])[CH:7]=1)([O-:5])=[O:4].O1CCCC1.[Cl-].[Na+]>O>[N+:3]([C:6]1[C:10]([CH2:11][OH:12])=[CH:9][N:8]([CH2:13][C:14]#[CH:15])[CH:7]=1)([O-:5])=[O:4]

Participants

6

Reactant 4

HCID 5234Sodium ChlorideHCID 8028TetrahydrofuranHCID 4192641Potassium borohydrideHCID 13605018HCID 13605018, compound

Product 1

HCID 13605019HCID 13605019, compoundYield 101.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

At 20° C., 242 mg of potassium borohydride were introduced into a solution of 400 mg of the product of Step A, 30 ml of tetrahydrofuran and 4 ml of water and the mixture was stirred for 15 minutes at ambient temperature. 10 ml of a saturated aqueous solution of sodium chloride were added with stirring for 5 minutes at 20° C. and after extracting with ethyl acetate, drying and concentrating, 410 mg of 3-nitro-1-(2-propynyl)-1H-pyrrole-4-methanol were obtained melting at 60° C.

Workup

  1. stirringwith stirring for 5 minutes at 20° C.
  2. extractionafter extracting with ethyl acetate
  3. customdrying
  4. concentrationconcentrating

Sources & evidence

ORD record
ord-30790f7e8c4043ad9d9556163e68cfcf
Source dataset
uspto-grants-1988_04
Patent number
US04737513

Reaction notes

Loading…