Trifluoroacetic acid → HCID 131715493, compound

HRID 649090Notes

Reaction equation

HRID 649090 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:8]([NH:10][C@H:11]([C:16]([O:18][CH3:19])=[O:17])[CH2:12][CH2:13][CH2:14][CH3:15])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>>[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:16]([O:18][CH3:19])=[O:17])[CH2:12][CH2:13][CH2:14][CH3:15])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[F:30][C:29]([C:27]([OH:33])=[O:28])([F:32])[F:31]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131715495HCID 131715495, compound

Product 1

HCID 131715493HCID 131715493, compound

Procedure

The protected dipeptide ester (XI) (4.8 g, 13 mmol) was dissolved in cold TFA (40 ml). After 10 minutes, the TFA was removed in vacuo and dry ether (200 ml) was added. The ether was decanted and the residue was washed with more ether (100 ml). The oily material was dried over KOH to give (XII) as a white foam that was used immediately, T.l.c. RfA3 =0.42.

Workup

  1. customthe TFA was removed in vacuo and dry ether (200 ml)
  2. additionwas added
  3. customThe ether was decanted
  4. washthe residue was washed with more ether (100 ml)
  5. dry with materialThe oily material was dried over KOH

Sources & evidence

ORD record
ord-78b5d809d6964058ba599bdb16aa965b
Source dataset
uspto-grants-1988_04
Patent number
US04737487

Reaction notes

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