Methyl iodide → HCID 86742104, compound

HRID 649109Notes

Reaction equation

HRID 649109 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([O:12][C:13]1[CH:26]=[CH:25][C:16]([O:17][CH:18]([CH3:24])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][CH:14]=1)=[CH:5]2.[CH3:27][I:28]>ClCCl>[I-:28].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:27])[CH2:7][C:6]([O:12][C:13]1[CH:14]=[CH:15][C:16]([O:17][CH:18]([CH3:24])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:25][CH:26]=1)=[CH:5]2

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20142094HCID 20142094, compound

Product 1

HCID 86742104HCID 86742104, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethyl 2-{4-[(6-chloro-1-methylquinolin-3-yl)oxy]phenoxy}propionate iodide salt (8) was prepared by reacting a mixture of ethyl 2-{4-[(6-chloroquinolin-3-yl)oxy]phenoxy}propionate (see Example 7) and methyl iodide in dichloromethane at ambient temperature for a period of four days. The product, a viscous oil, was characterized by its proton magnetic resonance spectrum. Pmr spectrum (CDCl3 ; in ppm): 10.1 (1H, d); 8.8 (1H, d); 8.65 (1H, d); 8.5 (1H, d); 8.05 (1H, d of d); 7.3 (4H, d of d); 4.95 (4H, m); 4.25 (2H, q); 1.6 (3H, d); 1.2 (3H, t).

Sources & evidence

ORD record
ord-67c4db50277f47e490cb46b59eab46d6
Source dataset
uspto-grants-1988_04
Patent number
US04738710

Reaction notes

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