Formaldehyde → 1,4-Bis[6-(3,4-dichlorophenyl)-3(2H)-pyridazinon-2-yl-methyl]piperazine

Participants

Reaction Steps

To 40 ml of methanol were added 1.0 g of 6-(3,4-dichlorophenyl)-3(2H)-pyridazinone, 0.2 g of paraformaldehyde and 0.25 g of piperazine, and the resulting mixture was heated under reflux for 2 hours. The mixture was then left to cool, after which insolubles were collected by filtration and dried, to give 1.1 g (yield 88%) of the desired Compound No. 34, melting at 271°-272° C.

Provenance & Evidence